A new view of microscopic processes

New equipment for a specialized electron microscope at the University of Missouri is added with the support of a $800,000 grant from the National Science Foundation.

four people looking at a computer screen in a lab
The new equipment will allow the University of Missouri researchers to gain a greater understanding of what’s going on at the most basic level of material’s structure by seeing an entire experiment unfold in real time. They will be able to see what's happening inside the electron microscope by viewing an experiment on these computer screens located in the Electron Microscopy Core (EMC) facility at the Roy Blunt NextGen Precision Health building. Top row (left to right): Jaewon Lee and Matthias Young. Bottom row: Xiaoqing He and Matt Maschmann. Pate McCuien/University of Missouri

March 20, 2023
Contact: Eric Stann, 573-882-3346, StannE@missouri.edu  

For more than 20 years, Matt Maschmann, an associate professor of mechanical and aerospace engineering at the University of Missouri, has worked with materials that require specialized technology — electron microscopes — to be seen by the human eye.

“When we deal with materials interacting on a nanoscale level, we can’t physically see the processes that are occurring, like the charging and discharging of a battery, for instance, without the help of an electron microscope,” Maschmann said.

person works on multiple computer screens
Xiaoqing He, a senior scientist in the Electron Microscopy Core facility, works to adjust images from an electron microscope showing an experiment happening in real-time. Pate McCuien/University of Missouri

Now, with the support of a two-year, $800,000 grant from the National Science Foundation and an additional $300,000 from the university, Maschmann and a team of researchers at MU are purchasing new equipment from Protochips which will allow researchers to conduct scientific experiments while simultaneously viewing reactions as they happen in real time — under the lens of a Thermo Fisher Scientific Spectra 300 Transmission Electron Microscope (TEM), housed in the Electron Microscopy Core (EMC) facility located in the Roy Blunt NextGen Precision Health building.

“The TEM is capable of letting researchers visualize reactions and material changes with up to atomic resolution, which is amazing,” Maschmann said. “But conducting experiments within a TEM environment is challenging because only small amounts of material will fit into a TEM chamber, and the system operates in a high-vacuum environment. Traditionally, researchers acquire TEM images of what a material looks like before and after an experiment, which leaves them to make an educated hypotheses about why and how a material has changed.”

new equipment for an electron microscope
The new equipment can help researchers with conducting experiments in three different environments — liquid, gas or vacuum — within the electron microscope. These new capabilities will allow them to explore and observe how different materials react to different environmental stimuli, like heat or electricity. Pate McCuien/University of Missouri

With the new equipment, Maschmann said researchers will be able to gain a greater understanding of what’s going on at the most basic level of material’s structure by seeing an entire experiment unfold in real time. He said they can also use the new equipment to conduct experiments in three different environments — liquid, gas or vacuum — within the electron microscope. These new capabilities will allow them to explore and observe how different materials react to different environmental stimuli, like heat or electricity.

“For instance, we will be able to examine the composition of nanomaterials all the way down to the atomic level,” said Maschmann, who became interested in doing scientific research by working as an undergraduate student with Hongbin “Bill” Ma, who is now one of his colleagues at MU. “We can obtain detailed measurements by seeing the atoms moving and can even determine what element the atoms are.”

Person working on equipment next to an electron microscope
Xiaoqing He, a senior scientist in the Electron Microscopy Core facility, works to connect the new equipment with a Thermo Fisher Scientific Spectra 300 Transmission Electron Microscope located in the Roy Blunt NextGen Precision Health building. Pate McCuien/University of Missouri

The new equipment also includes active image stabilization, which prevents images from moving, blurring or going out of focus while researchers follow a reaction.

“If we didn't have that [active image stabilization], it would be a big problem with these types of experiments,” Maschmann said. “For example, if we rapidly heat up a material, it's going to expand and move. So, if our original field of view is only a few hundred nanometers, as soon as heat is applied our area of interest will move beyond our original viewing area. Therefore, we would likely miss the reaction that we intended to observe.”

person looks at a computer screen
Xiaoqing He, a senior scientist in the Electron Microscopy Core facility, prepares to use the active image stabilization, which prevents images from moving, blurring or going out of focus while researchers follow a reaction. Pate McCuien/University of Missouri

There’s still much to be explored at this level of material science, and Maschmann is excited for the opportunities that this new equipment can provide to help advance scientific research across MU and beyond. The EMC facility is available to support scientific research by faculty from any of the four UM System universities, and that includes the new equipment for the TEM, he said.

The grant also highlights an interdisciplinary collaboration between the EMC and the MU Materials Science & Engineering Institute (MUMSEI). The goal of MUMSEI, which opened in 2021 as a partnership between the MU College of Engineering and the MU College of Arts and Science, is to advance collaboration around materials research and engineering education across the university. Maschmann is also the co-director of MUMSI. 

Portrait of researchers in front of an electron microscope
The research team at the University of Missouri includes (from left) Matthias Young, Jaewon Lee, Matt Maschmann and Xiaoqing He. Pate McCuien/University of Missouri

“MRI: Acquisition of Active Holders for in-situ and in-operando Transmission Electron Microscope Experiments,” was awarded by the National Science Foundation (2216026). Matthias J. Young, Xiaoqing He, Jaewon Lee and Maria Mills at MU are also involved with this project. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

Highlighting the promise of personalized health care and the impact of large-scale interdisciplinary collaboration, the NextGen Precision Health initiative is bringing together innovators from across the University of Missouri and the UM System’s three other research universities in pursuit of life-changing precision health advancements. It’s a collaborative effort to leverage the research strengths of Mizzou toward a better future for the health of Missourians and beyond. The Roy Blunt NextGen Precision Health building at MU anchors the overall initiative and expands collaboration between researchers, clinicians and industry partners in the state-of-the-art research facility.

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